Answers to Editor
The authors thank the edithor for positive general comment.

All the remarks made by the Editor have been taken as follows.

Editorial comments:

1. The editor has formatted the manuscript to match the journal's style. Please retain the same.

Done

2. Please address all the specific comments marked in the manuscript.

Done

3. Please do not use commercial terms in the manuscript. This includes trademark symbols (™), registered symbols (®), and company names before an instrument or reagent. All commercial products should be sufficiently referenced in the Table of Materials and Reagents.

Done

4. For the protocol section please ensure that you use imperative tense throughout the protocol as if directing someone how to do your experiment. Please provide all specifics with respect to your experiment.

Done 

6. Please ensure you answer the “how” question, i.e., how is the step performed?

Done

7. Please provide hard ex[erimental steps/ graphical user interface/ button clicks etc in the action steps.

Done

8. Once done please ensure that the protocol is no more than 10 pages and the highlight is no more than 2.75 pages including heading and spacings.

Done

9. The highlighted steps form a cohesive narrative with a logical flow from one highlighted step to the next. Please include all relevant details that are required to perform the step in the highlighting. For example: If step 2.5 is highlighted for filming and the details of how to perform the step are given in steps 2.5.1 and 2.5.2, then the sub-steps where the details are provided must be highlighted.

Done